Why Can’t a Human Heart Regenerate After a Heart Attack?

In: Science

Submitted By chirspepping
Words 1074
Pages 5
A number of organs in the human body have very restricted ability to regenerate after injury. For over 150 years, many research had been conducted regarding heart regeneration but many findings were extremely controversial (Carvalho and de Carvalho 2010). The heart is one of the most important organs as it’s responsible for the body’s oxygen and blood supply. The human heart is divided into four chambers and is enclosed in a fluid filled sac within the chest cavity. One of the least regenerative organs in the human body is the heart but if there is a regenerative response, it is small in comparison to that of other organs such as the liver and skin (Laflamme and Murry 2011). But why can’t the heart regenerate after a heart attack compared to other organs that can is the question and the cells that makes up the tissue can explain this.

The incapability of the human heart to regenerate after injury such as a heart attack (Myocardial infarction) poses a major difficulty in the cardiovascular medicine (Laflamme and Murry 2011). Heart attacks are caused by the disturbance of blood supply to parts of the heart, causing heart tissues to die, often due to the blockage of the coronary artery. The heart responds to a heart attack by scarring, which consequences in reduced cardiac function and to compensate for the reduced cardiac function, the heart then develops hypertrophy which in turn leads to heart failure (Lien et al. 2012). Marie et al. (1996) explain hypertrophy as the wall of the heart thickens in response to a heart attack, as the wall thickens the heart contracts less efficiently and pumps less blood around the body to tissues that leads to death. But the reason to why human heart can’t regenerate after a heart attack is due to the cells, cardiac myocytes which make up the tissues in the heart (Beltrami et al. 2001). Findings have shown that human cardiac…...

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