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Biochemistry GRT 1 DNA/RNA
Katharine K

Biochemistry GRT 1 DNA/RNA A. DNA Replication

B. The Role of the Ligase Enzyme in the replication of DNA

C. The Role of mRNA

D. Death Cap Mushrooms
The Death Cap Mushroom is an extremely toxic mushroom that is responsible for the majority of the mushroom poisoning deaths in the world. This fungi is also known as Amanita phalloides and is mainly found in Europe. It is found growing on the ground in woodlands and mountains.

This particular fungi contains two types of toxins, both are “ring-shaped peptides.” These toxins are amatoxins and phallotoxins and they target mainly the liver of the human body when ingested. RNA polymerase II is an essential enzyme in helpingour bodies produce messenger RNA (mRNA) as well as other RNA’s. The virulent function of the mushroom acts by stopping the movement of RNA polymerase II, transcription does not occur and therefore it does not produce mRNA. The amatoxin impedes RNA polymerase at both the initiation and the elongation phase. The translation phase will not happen now due to there being no mRNA available to make proteins. Protein synthesis cannot happen, cell metabolism stops and so the cell dies.
After human consumption of the mushroom, it initially can cause nausea and vomiting, but soon it affects the liver. The liver is the first organ to be damaged then the kidneys. Electrolyte imbalances begin and there would be no proteins like collagen to help with cell structure and reproduction, systems fail, and eventually, like the cell, the human dies. There is no cure.

Amanita Phalloides. (n.d.). In Wikipedia. Retrieved from http://en.wikipedia.org/w/index.php?title=Amanita_phalloides
DNA Replication. (n.d.). Retrieved from http://www.tokresource.org/tok_classes/biobiobio/biomenu/dna_replication/index.htm
Protein Synthesis [Internet].…...

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