Biocompatibility of Coronary Stents

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| Biocompatibility of Coronary Stents | | By | Josh DeBoer | Prepared for Dr. Lim Term PaperAdvanced Biomaterials (Engm 491)4/27/11 |


Right now, endovascular stents have less than desirable biocompatibility, resulting in many unwanted complications. Plasma activated coatings (PAC) have shown great promise to make endothelial cell interactions more active by using recombinant human tropoelastin. These articles seek to alter the plasma vapor composition of these coating properties by adding oxygen, argon, nitrogen, or hydrogen. Each of these gases had pros and cons, and these articles seek to find the best combination for these coatings.

Coronary heart disease (CHD) is the leading cause of death in the world, killing more than 15 million people according to the American Heart Association. It has many risk factors, including: * Diabetes * High blood pressure * High LDL "bad" cholesterol * Low HDL "good" cholesterol * Menopause * Not getting enough physical activity or exercise * Obesity * Radiotherapy to the chest, * Hypertension, * Hyperlipidemia. * Smoking
Coronary heart disease is usually caused by a condition called atherosclerosis, which occurs when fatty material and a substance called plaque builds up on the walls of a person’s arteries. This causes the coronary arteries to narrow, blocking or slowing blood flow to the heart, causing chest pain (stable angina), shortness of breath, heart attack, and other symptoms.
Coronary heart disease (CHD) alone is the primary cause of death in the United States, accounting for 20% of all deaths. CHD is partially caused by uncontrollable factors such as genetics and age, but fortunately, CHD is largely preventable. By examining the risk factors associated with CHD, one can maximize prevention recommendations and enhance their…...

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...Coronary heart disease (CHD), also called coronary artery disease, is a condition in which plaque (plak) builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart muscle. Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. When plaque builds up in the arteries, the condition is called atherosclerosis (ATH-er-o-skler-O-sis). The buildup of plaque occurs over many years. Figure A shows a normal artery with normal blood flow. Figure B shows an artery with plaque buildup. Over time, plaque hardens and narrows your coronary arteries. This limits the flow of oxygen-rich blood to your heart muscle. Eventually, an area of plaque can rupture (break open). This causes a blood clot to form on the surface of the plaque. If the clot becomes large enough, it can mostly or completely block blood flow through a coronary artery. TLC therapeutic lifestyle changes Health Information center: 301-592-8573 Unhealthy blood cholesterol levels. This includes high LDL cholesterol (sometimes called “bad” cholesterol) and low HDL cholesterol (sometimes called “good” cholesterol). High blood pressure. Blood pressure is considered high if it stays at or above 140/90 mmHg over time. If you have diabetes or chronic kidney disease, high blood pressure is defined as 130/80 mmHg or higher. (The mmHg is millimeters of mercury—the units used to measure blood pressure.) Smoking. Smoking can damage and tighten......

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