Amphetamine Use and Its Effects

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AMPHETAMINE USE AND ITS EFFECTS
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AMPHETAMINE USE AND ITS EFFECTS
Stimulant use by humans has a very long history. The Ma-huang drug has been used by the Chinese natives for more than 5000 years (Ebadi, 2002). The active agent of Mu-huang was found to be ephedrine in 1887. First synthesis of Amphetamine proper was in 1887 as part of a program for manufacturing aliphatic amines. At first, investigations on amphetamine properties concentrated on peripheral effects and it was found that it was a sympathomimetic agent having bronchodilator properties. However, the effect on the central nervous system was not reported until 1933 which was followed closely by the first amphetamine abuse reports. Amphetamines give people a feeling of relief from fatigue and euphoria, it produces anorexia, improves performance of doing simple tasks and increases the activity levels (Ebadi, 2002). Amphetamine abuse is considered to be related primarily to the euphorigenic effects that lead to its use in high doses before the onset of the final stage which is compulsive abuse.
The abuse of Amphetamines at present has been at low epidemic levels since the drug as introduced in the 1930s. During the beginning of the 1950s and 60s however, the epidemic appeared in the United States, Sweden and japan. A study of the epidemic reveals that there were several factors which contributed to its spread and these include; large population segments being introduced to the drug for recreational, medical and reduction of fatigue purposes, the quick spread of knowledge of the effects and experience of the use of amphetamines, the swelling of a large group of chronic users of amphetamines leading to the development of an illegal stable market for the drug, additional use of other methods of administration of the drug for example by smoking, there was an oversupply of…...

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